I would suggest that if you have areas that are difficult to remove to verify you've actually removed all the contaminants. I will say that on cars where I've clay/nanoskinned AND Chemically decontaminated the paint, I have no issues removing Adapt when used in right amounts. Swap Pads after two panels and do the above and I would be surprised if you have trouble.
AIO Wise, hands down HDSpeed. I only do this work on the side so 1 car per week, sometimes 2 and 90% of what I target is HDSpeed AIO applications.